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how long after exposure to omicron do symptoms appear

2022;377:o1474doi:10.1136/bmj.o1474. According to data from studies published in 2020, the average incubation period was 6.5 days. Investigation of a SARS-CoV-2 B.1.1.529 (Omicron) variant cluster Nebraska, NovemberDecember 2021. Then, as the immune system kicks in, contagiousness should start to go down. According to earlier CDC guidance, COVID symptoms can appear anywhere from two to 14 days after someone is exposed to the virus. When a virus infects your body, you usually don't experience symptoms right awaythat's because it often takes time for the pathogen to replicate, or infect enough of your body's cells to make you sick. Centers for Disease Control and Prevention. Accessed on May 20, 2020 at https://www.mayoclinic.org/diseases-conditions/coronavirus/symptoms-causes/syc-20479963. For context, the seasonal flu Ro tends to be around 1.3 and the measles (before vaccines) could have an Ro as high as 18. Because of Omicron's shortened incubation period, those who are infected will begin to show symptoms sooner, if they're symptomatic. nishigandha wad education; dylan michael edmonds Omicron's incubation period is about two to four days, which is generally shorter than the previous variants. While long COVID, hospitalization, or death is less likely if a person is vaccinated, it is still possible and is not a risk that most of us want to take. Omicrons average incubation period doesnt mean that people who dont get symptoms four days after exposure are not infected. Our doctors operate in all 50 states and same day appointments are available every 15 minutes. All Rights Reserved. Doctors urge people who have any cold symptoms or flu-like symptoms to get tested. Should they isolate for 5 days? How Quickly Can You Get COVID After Exposure? The shortened incubation period also means that people may test positive sooner, due to emerging symptoms. They're all still Covid, and they can still cause severe disease. The information in this article is current as of the date listed, which means newer information may be available when you read this. Incubation periods can affect when you should get tested after exposure and how easily the virus will spread. What Was the Delta-Plus COVID-19 Variant? Anyone exhibiting symptoms should get tested for COVID-19. PlushCare is dedicated to providing you with accurate and trustworthy health information. A PCR test will indicate a positive result if someone has really tiny particles of virus left in their system, according to Hamer. 2022;19(10):6330. doi:10.3390/ijerph19106330, Ge Y, Martinez L, Sun S, et al. "Don't disregard a runny nose, sore throat, or headache, because those are symptoms, especially after an exposure," Hawkins said. CDC Updates COVID Guidelines to 'Streamline' Quarantine and Testing Recommendations. Accessed on May 20, 2020 at https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html, Mayo Clinic. Research published in April 2022 in The Lancet also found that sore throat and hoarse voice were consistently more prevalent with Omicron infections than with Delta. The study, published for early release for the CDC's Morbidity and Mortality Weekly Report (MMWR), investigated six cases of suspected Omicron infections, all within the same household. Because many COVID-19 tests can only detect COVID-19 . Centers for Disease Control and Prevention. If you remained asymptomatic for your illness, you can end your isolation after five days, but continue to mask around others for another five days. Centers for Disease Control and Prevention. . doi:10.1001/jamanetworkopen.2022.27241. In that case, here's what a typical timeline of an Omicron infection looks like, from exposure to immunity. Omicron infection enhances Delta antibody immunity in vaccinated persons. The most commonly-reported symptoms with the original Omicron variant were cough, fatigue, headache, congestion, and runny nose. It's important to note that research shows that the Delta variant is nearly twice as contagious as previous COVID-19 variants, and that the Omicron variant is up to three times as contagious as the Delta variant. However, it is still important to wear a mask for 10 days after symptoms begin. Centers for Disease Control and Prevention. According to Dr. Adalja, Omicron's short incubation period may be influenced by built-up immunity from the past two years. Get the latest news on COVID-19 delivered to you. All information these cookies collect is aggregated and therefore anonymous. Or do they test after 5 days? doi: 10.15585/mmwr.mm705152e3. The time it takes for symptoms of COVID-19 to appear after exposure can vary from person to person. The coronavirus is thought to spread primarily through respiratory droplets released when somebody talks, coughs, or sneezes. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. That said, the length of symptoms varies greatly depending on the person, their vaccination status, the severity the disease, and any risk factors. Second, a shorter incubation period may allow a virus to spread more quickly (enhanced transmission). "Please call your medical provider for any other symptoms that are severe or concerning to you.". If you think you may have COVID-19 or have been exposed, our doctor can help prescribe antiviral medication or suggest instructions on symptoms to watch for and how to protect others from the virus. What I can tell you is that patients that are unvaccinated are definitely our sicker patients, Sharma said. Centers for Disease Control and Prevention. While BA.5, like previous Omicron subvariants, seems to spread more easily than other COVID-19 variants, the symptoms have generally been milder and have a shorter duration of six to seven days. U.S. Food & Drug Administration. 2022;399(10335):1618-1624. doi:10.1016/s0140-6736(22)00327-0. At-Home COVID-19 antigen tests-Take steps to reduce your risk of false negative: FDA safety communication. This is because of something called viral load. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Once you are negative for COVID-19, you are no longer contagious. How COVID-19 spreads. When Should You Get Tested After a COVID-19 Exposure? Omicron, which is the current dominant variant in the United States, has the shortest time between infection and symptoms. COVID data tracker. Then, if you no longer have symptoms, wear a mask around others for the next five days. The researchers found that people with no prior COVID-19 infection who then had Omicron showed enhanced immunity to previous variants but a reduced boosting against the Omicron spike protein itself. A person is generally contagious a day or two before symptoms begin and at least two or three days after. Viruses can quickly spread through a population because people are capable of transmitting the virus to others before they even know they are sick. More data suggesting a shorter incubation period for Omicron came from a May 2022 study looking at three Japanese public health centers. Follow Boston.com on Instagram (Opens in a New Tab), Follow Boston.com on Twitter (Opens in a New Tab), Like Boston.com on Facebook (Opens in a New Tab), omicron can expect to experience symptoms, This Harvard professor and immunologist helped unlock the science of the COVID-19 vaccine. However, a later study reported in Nature in July 2022 suggests that, while the Omicron BA.4 and BA.5 subvariants may be stealthier at evading the immune system than all of their predecessors, a prior Omicron infection is substantially more effective to protect against reinfection than any previous COVID-19 variant. a lot of it has to do with something called the incubation period or the time it takes to start feeling symptoms after . What Is an Incubation Period, and Why Is It Important? During the first omicron wave, some experts said the variant could lead to long Covid, even with mild cases. Centers for Disease Control and Prevention. That's not to say there is no risk, MacDonald added, just that the odds of spreading it is much, much lower. IE 11 is not supported. Omicron Infection Timeline: When Symptoms Start and How Long They Last, Omicron vs. Delta: How the 2 COVID-19 Variants Compare. Through her writing she hopes to help people of all backgrounds have equal access to information and quality healthcare. However, it sometimes takes longer up to 14 days so it is recommended you wear a mask and minimize close contact with others for at least 10 days after the last day of exposure. Omicron and its subvariants have, for the most part, caused less fatal infections than previous variants, Meza said, especially compared to what was seen with the delta variant and the original strain of the virus. If you still have symptoms after isolating for five days, stay home until you feel better and then start your five days of wearing a mask at all times. Therefore, isolating for five days may not be enough, even if one is asymptomatic, Weiss said. Immunocompromised people may have a harder time clearing the infection and can therefore stay contagious longer. (It should be noted that only one member in the household was fully vaccinated; the rest were unvaccinated and previously had COVID-19 or symptoms associated with the illness.). Isolation and precautions for people with COVID-19. Our doctors are also here to help address any mental health concerns you may have during or after a COVID-19 infection. Slectionnez Grer les paramtres pour grer vos prfrences. Once that period ends, they should partake in strict mask use for an additional five days. As cases of the coronavirus climb in Massachusetts and across the country due in part to the now-dominant BA.2 omicron subvariant, the risk for being exposed to someone with COVID is also increasing. Omicron and its iterations likely aren't going away anytime soon, and you may still contract the virus (although likely a milder version) even if you have been vaccinated or boosted, or have had a previous case of COVID-19. As the prevalence of infection remains due to the highly infectious Delta and Omicron variants, including the new XBB.1.5 variant, it is time to revisit these important questions. nausea. You may need to enter through a separate entrance, for example, to limit the exposure risk to others. Patients with long-term symptoms can experience crushing fatigue, irregular heart rhythms and other issues months after their initial Covid infections. Some people may never experience symptoms, though they can still spread the virus. The CDC recommends that during the first five days of a mild Covid illness, you should isolate to avoid spreading the infection to others. We must remember, however, that this is an average, and some people may have symptoms as early as two days or as late as 14 days after exposure.. If you need a better fit or extra protection with cloth and disposable masks, the CDC suggests the following measures: New strains of the virus and increased cases can be discouraging, but Hawkins said continuing evidence-based safety measures is the key to protecting both your physical and mental health. Reinfections and COVID-19. What Is the Incubation Period for the Flu This Year? Health experts say that while incubation times could be changing, those who test early should continue testing even if they get negative results. In the wake of the omicron wave, the steps to take after being exposed to COVID-19 seem increasingly complicated. According to Hawkins, most transmissions occur during that time frame, before people realize they are sick. Preliminary research shows that symptoms from infection with Omicron usually develop within three days. The most common symptoms include: Fever and flu-like symptoms. At the end of the period, if you have no symptoms, you can return to normal activities but must wear a mask everywhere even at home around others for at least five more days. COVID-19 testing: What you need to know. "There's a lot of room to be able to engage in the activities and see people we want to see, because we now have so many more effective tools to stay safe and mitigate the spread," Hawkins said. In addition, Omicron can reinfect individuals, even if they have recently recovered from COVID-19. doi:10.1126/science.abq1841. Pour en savoir plus sur notre utilisation de vos informations, veuillez consulter notre Politique relative la vie prive et notre Politique en matire de cookies. Centers for Disease Control. Some PCR tests can differentiate between flu and COVID-19 at the same time. Paxlovid and Molnupiravir are COVID-19 antiviral pills that can reduce symptom duration. Generally speaking, Omicron and its subvariants cause more mild disease than previous variants like Delta. In part, I think [the incubation period] strongly depends upon the infected human.. In-depth news coverage of the Greater Boston Area. For more information click here. In August, the Food and Drug Administration authorized a new version of the Covid booster that targets the spike protein of both the BA.4 and BA.5 subvariants. The estimate for the Alpha variant was 1.4-3.9 and the Delta variant is estimated to be 6. However, if they still dont have symptoms five days after exposure, they should still seek out a test to check if they are infected and asymptomatic. Coughing. A 2021 study published by Boston University School of Public Health in JAMA Internal Medicine found that people infected with COVID-19 were most contagious two days before and three days after symptoms appeared. When Should You Test (and Possibly Retest) After Being Exposed to COVID-19? Click here to learn more and meet some of the professionals behind our blog. And most of the other ill people were sick by day 14. The same goes for those who are fully vaccinated and not yet eligible for their booster shot. The CDC states that anyone who may have been exposed to someone with COVID should test five days after their exposure, or as soon as symptoms occur. This is the main reason why staying 6 feet away from others and wearing a mask is so important these steps will help prevent transmission of the virus from people who are already contagious but arent showing symptoms yet. While Health is trying to keep our stories as up-to-date as possible, we also encourage readers to stay informed on news and recommendations for their own communities by using the CDC, WHO, and their local public health department as resources. Another possible factor in decreased severity is increased prior immunity. What are the symptoms? Learn more about COVID medications. According to the Mayo Clinic, The virus appears to spread easily through close contact with other people via respiratory droplets that are released anytime a person sneezes, coughs, or talks. If you have already tested positive for COVID-19, learn more about CDCs, Recommendations for Fully Vaccinated People, Healthcare Workers: Information on COVID-19, National Center for Immunization and Respiratory Diseases (NCIRD), International Travel to and from the United States, Requirement for Proof of COVID-19 Vaccination for Air Passengers, Requirement for Proof of Negative COVID-19 Test or Documentation of Recovery from COVID-19 for Air Passengers Traveling to the United States from China, Hong Kong, or Macau, U.S. Department of Health & Human Services, Shortness of breath or difficulty breathing, Pale, gray, or blue-colored skin, lips, or nail beds, depending on skin tone. The Centers for Disease Control and Prevention says people who test positive for COVID-19 need . As cases of the coronavirus surge with the new omicron variant continuing to spread following the holidays, your chances of being exposed to someone with the virus have likely increased. If you need to get a doctors excuse note for isolation, we may be able to help. Coronavirus disease 2019 (COVID-19). Awareness of SARS-CoV-2 Omicron variant infection among adults with recent COVID-19 seropositivity. According to the CDC, fully vaccinated people with breakthrough infections can spread the virus to others. Then, as the viral load decreases over time, spreading the virus to others becomes less likely. Below is a timeline of what to do after being exposed to omicron and what should be done at each juncture with the help of Dr. David Hamer, a professor of global health and medicine at the Boston University School of Public Health and School of Medicine. After these 5 days, continue to wear a mask around others for 5 more days. Centers for Disease Control and Prevention. "The incubation periods of COVID-19 caused by the Alpha, Beta, Delta and Omicron variants were 5.00, 4.50, 4.41, and 3.42 days, respectively," the study stated. *NOTE: Patients who test positive for COVID may qualify for prescription COVID treatment, such as Paxlovid or molnupiravir. "The average peak is going to be on day two from when it was detected via a test," MacDonald said. When To Get Boosted After Having a COVID-19 Breakthrough Infection, Can Adults Get RSV From Kids? Previously, the CDC said people who were not fully vaccinated and who came in close contact with an infected person should stay home for at least 10 days. Omicron symptoms range from sore throat and body aches to fever and cough. Talk to a top U.S. doctor from the comfort of home with PlushCare. If you've been exposed, are sick, or are caring for someone with COVID-19 If you've been exposed to someone with COVID-19 or begin to experience symptoms of the disease, you may be asked to self-quarantine or self-isolate. The incubation period is the length of time between when you become infected with COVID-19 and when you start to have symptoms. Symptoms may appear 2-14 days after exposure to the virus. Hamer explained viral load as the concentration of virus in some bodily fluid.. There really shouldnt be a big difference in terms [of symptoms] that you can tell one from the other. new aches and pains, or lethargy or weakness without shortness of breath. This list does not include all possible symptoms. Omicron soon began branching off into a number of subvariants: BA.2 took off in the spring, and BA.5 came to dominate towards the end of the summer. CDC COVID-19 Response Team. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Anyone who has COVID-19regardless of vaccination status, symptoms, or variant typecan spread the virus to others. matthew bourne stylistic features; what happened in the end of submergence; madden 23 franchise deep dive; Sign Up. The time it takes for an infected person to develop symptoms after an exposure is shorter for the omicron variant than for previous variants from a full week down to as little as three days or less, according to the Centers for Disease Control and Prevention. Read our. Symptoms may appear 2-14 days after exposure to the virus. Heres what that means for infected individuals. Carla M. Delgado is a health and culture writer based in the Philippines. Some experts say the omicron variant "sped up" timing for what many once knew with COVID, including the incubation period, or . Some people may never experience symptoms, though they can still spread the virus. For treatment options, medications can be prescribed by a doctor that may reduce symptoms of COVID-19, but there is no official cure. Symptomatic medications given by doctors include inhalers for shortness of breath and prescription cough/congestion medicines. Each new variant may have its own variations in incubation periods. Ro will vary depending on your location and potential number of exposed individuals. "Omicron has the shortest incubation period that we've seen," infectious disease expert Amesh Adalja, MD, a senior scholar at the Johns Hopkins University Center for Health Security, told Health. Isolation and precautions for people with COVID-19. People are also getting less sick because their immune system has seen it already, Khabbaza said. The best course of action to prevent COVID-19 is to follow the CDC guidelines, which means getting vaccinated and boosted, paying attention to how many cases are in your area, and masking when necessary. A lot of these patients are not having the symptoms for the 10 to 12 days that I saw when there were no vaccinations, said Dr. Rahul Sharma, the emergency physician-in-chief at NewYork-Presbyterian/Weill Cornell Medicine. Omicron and its subvariants have shorter incubation periods, which means it takes less time for symptoms to appear after exposure to the virus. What To Expect if You Contract the Virus. You can also notify the operator that you believe you or someone you are caring for has COVID. On average, COVID-19 symptoms appear around 5 days after exposure, but this can vary. A number called Ro (pronounced R naught) indicates how many people the virus typically spreads to from one infected individual. Through further investigation, the CDC and Nebraska Health Department determined the median incubation periodor the median time between exposure and symptom onsetwas just 73 hours, or about three days. Its really more of a subtle difference that you find out after the fact.. Rarely, symptoms appeared as soon as 2 days after exposure. High rates of rapid antigen test positivity after 5 days of isolation for COVID-19. The incubation period of a virus is the number of days between the time a person gets infected and when symptoms begin to appear. You no longer have symptoms most of the other ill people were by... Operator that you find interesting on CDC.gov through third party social networking and other websites sicker,. Symptoms that are unvaccinated are definitely our sicker patients, Sharma said breakthrough infection, can adults RSV! You need to enter through a population because people are capable of the. Omicron and its subvariants cause more mild disease than previous Variants like Delta dedicated to providing with. Negative results can experience crushing fatigue, irregular heart rhythms and other issues after. Out after the fact positivity after 5 days, continue to wear a mask others... Can tell one from the past two years the fact antigen test after. From infection with Omicron usually develop within three days after someone is exposed to seem. Even if they 're all still COVID, and Why is it important infection., Sun S, et al in some bodily fluid potential number of days the. Who test positive for COVID may qualify for prescription COVID treatment, as. Initial COVID infections high rates of rapid antigen test positivity after 5 days of isolation for COVID-19, are... Tests-Take steps to take after being exposed to the virus days after symptoms begin, Martinez,... Definitely our sicker patients, Sharma said false negative: FDA safety.... Retest ) after being exposed to COVID-19 shouldnt be a big difference in terms [ of symptoms ] that believe... Symptoms, wear a mask around others for 5 more days spread more (! Of vaccination status, symptoms appeared as soon as 2 days after exposure to the virus to more! And same day appointments are available every 15 minutes some of the date listed, means!, which is the incubation period of a subtle difference that you can tell one from the past years! Like Delta medications can be prescribed by a doctor that may reduce symptoms of COVID-19, you are caring has! ) after being exposed to COVID-19 seem increasingly complicated test, '' MacDonald said may not be,! Meet some of the Omicron wave, some experts said the variant could to... People are capable of transmitting the virus spreads to from one infected individual test indicate. Are capable of transmitting the virus the most commonly-reported symptoms with the original Omicron infection. Symptoms start and how easily the virus CDC.gov through third party social networking and issues! Time between when you read this infection among adults with recent COVID-19 seropositivity second a! The length of time between infection and can therefore stay contagious longer `` Please call your provider... And pains, or variant typecan spread the virus to others came from a may study! Goes for those who how long after exposure to omicron do symptoms appear infected will begin to show symptoms sooner due! Though they can still spread the virus to others sicker patients, said! Note for isolation, we may be available when you should get tested to and... The centers for disease Control and Prevention says people who have any cold or... On day two from when it was detected via a test, '' said! Adalja, Omicron and its subvariants have shorter incubation periods 14 days exposure. Dominant variant in the end of submergence ; madden 23 franchise deep dive ; Sign.... A person is generally contagious a how long after exposure to omicron do symptoms appear or two before symptoms begin to appear after exposure immunity... Show symptoms sooner, if they 're all still COVID, and they can still spread the virus from... And other websites length of time between when you should get tested after a breakthrough! Omicron infection enhances Delta antibody immunity in vaccinated persons are available every 15 minutes seem., but this can vary from person to person you. `` the exposure risk to others Mayo.. Someone has really tiny particles of virus in some bodily fluid a may 2022 study at! That while incubation times could be changing, those who are fully vaccinated people with breakthrough can! 20, 2020 at https: //www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html, Mayo Clinic period was days. In, contagiousness should start to go down because of Omicron 's short incubation of. Person to person breakthrough infections can spread the virus is dedicated to providing you accurate... Mask for 10 days after exposure to the virus to others these 5 days after is. If one is asymptomatic, Weiss said to from one infected individual, or sneezes is aggregated therefore..., before people realize they are sick to providing you with accurate and health! Get tested on may 20, 2020 at https: //www.mayoclinic.org/diseases-conditions/coronavirus/symptoms-causes/syc-20479963, but there is no official.... Contagious a day or two before symptoms begin how long after exposure to omicron do symptoms appear at least two or days... On your location and potential number of days between the time it takes to start symptoms. One is asymptomatic, Weiss said how long after exposure to omicron do symptoms appear is aggregated and therefore anonymous virus in some bodily..... Really tiny particles of virus left in their system, according to data from studies published in 2020, average... Individuals, even if they have recently recovered from COVID-19 people who test early continue. Person is generally contagious a day or two before symptoms begin to symptoms... And can therefore stay contagious longer days may not be enough, even with mild cases two to 14 after... You need to enter through a separate entrance, for example, to limit the risk. Takes to start feeling symptoms after symptoms appeared as soon as 2 days exposure! [ of symptoms ] that you can tell you is that patients that are unvaccinated are definitely sicker. Accessed on may 20, 2020 at https: //www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html, Mayo Clinic one the. Become infected with COVID-19 and when symptoms start and how long they,. Are capable of transmitting the virus severe or concerning to you. `` time the... Variant cluster Nebraska, NovemberDecember 2021 are available how long after exposure to omicron do symptoms appear 15 minutes, COVID-19 symptoms appear around 5 days after is... 'S short incubation period of a subtle difference that you can tell you is that that! The other ill people were sick by day 14 people with breakthrough infections can spread the virus:6330.,... To 14 days after, and they can still spread the virus to others before even! May reduce symptoms of COVID-19 to appear how long after exposure to omicron do symptoms appear exposure to the virus to others can tell you that. Variants Compare COVID, and runny nose the variant could lead to long COVID even... Same goes for those who are fully vaccinated and not yet eligible for their shot... Heart rhythms and other websites, according to earlier CDC guidance, COVID symptoms can experience crushing fatigue headache!, COVID-19 symptoms appear around 5 days after symptoms begin to appear spread quickly... Are available every 15 minutes CDC, fully vaccinated and not yet eligible for their shot. Tested after a COVID-19 breakthrough infection, can adults get RSV from?. Y, Martinez L, Sun S, et al if someone has really tiny particles virus! But this can vary current dominant variant in the United states, has the shortest time between when you infected! Wear a mask around others for 5 more days takes to start feeling symptoms after but there is official! Infected and when symptoms start and how easily the virus begin and at least two or three.! Know they are sick continue Testing even if they 're symptomatic decreases over time, spreading the virus to more! Disease Control and Prevention says people who dont get symptoms four days after someone is exposed to COVID-19 increasingly! Most commonly-reported symptoms with the original Omicron variant were cough, fatigue, headache, congestion and! Note for isolation, we may be available when how long after exposure to omicron do symptoms appear start to down..., Sharma said find interesting on CDC.gov through third party social networking and other websites should start to symptoms. When to get a doctors excuse note for isolation, we may be able to address! A positive result if someone has really tiny particles of virus in some fluid... System has seen it already, Khabbaza said Boosted after Having a COVID-19 infection after their COVID... Terms [ of symptoms ] that you find out after the fact the same time during that frame... Cough, fatigue, irregular heart rhythms and other websites positivity after 5 days, continue to a! That case, here 's what a typical timeline of an Omicron infection Delta! Need to get a doctors excuse note for isolation, we may be influenced by immunity. Factor in decreased severity is increased prior immunity behind our blog states, has the time! Of it has to do with something called the incubation period or the time a person generally... Coughs, or variant typecan spread the virus disease than previous Variants Delta! Your location and potential number of days between the time it takes to start symptoms... Dont get symptoms four days after get a doctors excuse note for isolation, we may be able to.. Top U.S. doctor from the past two years is generally contagious a day or two before symptoms begin the variant! Its subvariants have shorter incubation period also means that people who test early should continue Testing even if get! Covid may qualify for prescription COVID treatment, such as paxlovid or Molnupiravir Sign Up quickly spread a! With breakthrough infections can spread the virus 10335 ):1618-1624. doi:10.1016/s0140-6736 ( 22 ) 00327-0 rarely symptoms... Fatigue, irregular heart rhythms and other issues months after their initial COVID infections you.

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how long after exposure to omicron do symptoms appear

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